Research Core Facilities provide specialized services to the research community on a fee-for-service basis. Cores facilitate research by enabling investigators to outsource experiments that require specialized knowledge and technical abilities not found in most laboratories. Because of the nonprofit design of cores, service pricing is significantly below that of commercial entities providing similar services.
The Flow Cytometry Core is committed to providing quality state-of-the-art flow cytometry including cell cycle, cell proliferation, apoptosis, cell viability, cell signaling, stem cell detection, fluorescent protein analysis, and cell phenotyping along with cell sorting. Instrument training and experimental design assistance is available for those who are not familiar with flow cytometry. The core specializes in high-end equipment that can perform sophisticated multicolor analysis and sorting in addition to more standard assays. Core equipment consists of three standard fluorescence-based cell analyzers that detect up to 27 colors, a spectral analyzer that can detect greater than 30 colors, three high-speed MoFlo cell sorters, a Sony MA900 cell sorter, a Fluidigm Helios mass cytometer, and a Luminex Magpix multiplex bead analyzer. For more information, visit our website at http://flowcytometry.coloradocancercenter.org or email firstname.lastname@example.org.
The Histology Core provides investigators and their research teams with the tools, knowledge, and technical expertise needed to process and analyze their tissue samples. The Core offers a wide array of services including paraffin and OCT embedding, sectioning of frozen and paraffin blocks, as well as routine (H&E) and special staining for all types of tissues. Other histological services are available upon request. Finally, consultations are available to investigators as necessary. Click here for more information.
The Stem Cell Biobank and Disease Modeling Core (SCB&DM core offers complete services related to the production of high-quality human induced pluripotent stem cells (iPSCs) from patient-derived somatic cells. The core employs a patent-pending, RNA-based methodology to reprogram human somatic cells, such as dermal fibroblasts, urine derived renal epithelial cells, and amniotic fluid derived stem cells, into iPSCs. The RNA-based technology eliminates the possibility of confounding insertional mutagenesis events and consistently reprograms healthy, disease-associated and aged/senescent somatic cells into high-quality iPSCs with an ultra-high efficiency (up to 90%). For further information, please visit our website at: https://www.ucdenver.edu/academics/colleges/medicalschool/centers/StemCell/BioBank%20Core/Pages/Overview.aspx
Gates Institute’s affiliated Gates Biomanufacturing Facility is one of six combined cell therapy and protein manufacturing facilities in the United States and the only one of its kind within an 800-mile radius. The facility has been a key element in the recruitment and retention of some of the nation’s top regenerative medicine researchers for the CU Anschutz Medical Campus.
The Gates Biomanufacturing Facility at the University of Colorado Anschutz Campus provides the following services: process development, scale up, manufacturing of both cell therapy- and protein-based products to cGMP standards, and process documentation to academic researchers, clinicians and early stage biotechnology companies. Utilizing its expertise in quality assurance and control and process development and manufacturing, facility staff help translate bench scale processes to optimized clinical-ready manufacturing processes and perform product manufacturing for early-phase clinical trials. By leveraging our existing current Good Manufacturing Practice (cGMP) facility, trained personnel, qualified equipment and best practices across each of our support services, investigators can significantly accelerate their timeline while minimizing their overall investment.
Business development, research finance assistance and regulatory and commercialization support: for further information, see: Commercialization
A key part of Gates Institute's mission is to serve as a focal point for recruitment and retention of top research talent for Colorado, tapping into the resources of the Anschutz Medical Campus and our collaborative partners. Pillars of Gates Institute, including the Gates Biomanufacturing Facility and the Grubstake Fund, have proven attractive to top national researchers and highly-regarded Anschutz researchers as they seek to move their discoveries toward treatments in human patients.
Gates Institute works closely with partners to identify and reach out to top researchers. Our partners include CU Boulder, Anschutz Medical Campus, the University of Colorado School of Medicine, UCHealth, Children’s Hospital Colorado, Colorado State University, Colorado School of Mines, and private industry.
The Gates Summer Internship Program (GSIP) encourages outstanding undergraduates to consider careers in biomedical research in an academic or industry setting by providing state-of-the-art training opportunities at Gates Institute.
A committee of Gates Institute faculty selects highly qualified undergraduates to work full-time in laboratories at the University of Colorado Anschutz Medical Campus.
Gates Institute also supports the Graduate Program in Cell Biology, Stem Cells and Development (CSD) directed by Jeff Moore, PhD, Gates Institute member and Diane G. Wallach Chair in Pediatric Stem Cell Biology. This combined program is based on the premise that although medical use of stem cells holds great promise for treatment of human diseases and birth defects, to advance the use of stem cells in the clinic scientists must continue to pursue fundamental discoveries as to how cells function and how cells in embryos form the different tissues of the body.
As explained by Bruce Appel, PhD, former director of the CSD program, “CSD students and faculty have common interests in understanding the molecular and cellular mechanisms that underlie development, disease, stem cell biology and regeneration—a common curiosity that promotes extensive interaction among labs and creates a fantastic intellectual environment.”